1.Using the applet supplied in this lab in the lab data link, look at the structure of HIV-1 reverse transcriptase. a) Is the enzyme a monomer (1

1.Using the applet supplied in this lab in the lab data link, look at the structure of HIV-1 reverse transcriptase.

a) Is the enzyme a monomer (1 chain), a dimer (2 chains), a trimer (3 chains), etc.?

b) Which chain is composed of greatest number of amino acids?

c) Which chain has the greater number of alpha helix segments?

d) What is the most predominant amino acid in each chain?

2.Using the applet supplied in this lab in the lab data link, look at the structure of the HIV-1 reverse transcriptase inhibitor.

a) Select the miscellaneous molecule (inhibitor), display it in atom and bonds format, save it as a jpg and upload it into your lab report without the enzyme subunits.

b) How many atoms does it possess (excluding hydrogen atoms as shown)?

3. What property of HIV-1 reverse transcriptase makes it difficult to use single drugs that remain effective in treating infection? Hint: It is a property that our DNA and RNA polymerases have evolved to avoid.

Maximum number of words: 300

Chain A is purple. Chain B is green . Ligand attached to purple chain.

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